PML/RARα-regulated miR-181a/b-cluster targets the tumor suppressor RASSF1A in Acute Promyelocytic Leukemia

In acute promyelocytic leukemia (APL), all-trans-retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. MicroRNAs are known to be critical players in the formation of the leukemic phenotype. In this study, we report downregulation of the miR-181a/b gene cl...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Bräuer-Hartmann, Daniela, Hartmann, Jens-Uwe, Wurm, Alexander A., Gerloff, Dennis, Katzerke, Christiane, Falzacappa, Maria Vittoria Verga, Pelicci, Pier Giuseppe, Müller-Tidow, Carsten, Tenen, Daniel G., Niederwieser, Dietger, Behre, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537849/
https://ncbi.nlm.nih.gov/pubmed/26041820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3521
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