Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia

The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm...

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Hlavní autoři: Katzerke, Christiane, Madan, Vikas, Gerloff, Dennis, Bräuer-Hartmann, Daniela, Hartmann, Jens-Uwe, Wurm, Alexander Arthur, Müller-Tidow, Carsten, Schnittger, Susanne, Tenen, Daniel G., Niederwieser, Dietger, Behre, Gerhard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790511/
https://ncbi.nlm.nih.gov/pubmed/23974200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-472183
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