C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations

The transcription factor, CCAAT enhancer binding protein alpha (C/EBPα), is crucial for granulopoiesis and is deregulated by various mechanisms in acute myeloid leukemia (AML). Mutations in the CEBPA gene are reported in 10% of human patients with AML. Even though the C/EBPα mutants are known to dis...

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Main Authors: Pulikkan, John A., Peramangalam, Philomina S., Dengler, Viola, Ho, Phoenix A., Preudhomme, Claude, Meshinchi, Soheil, Christopeit, Maximilian, Nibourel, Oliver, Müller-Tidow, Carsten, Bohlander, Stefan K., Tenen, Daniel G., Behre, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031410/
https://ncbi.nlm.nih.gov/pubmed/20889924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281600
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