Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα induced granulocytic differentiation via c-Jun in AML

The transcription factor C/EBPα plays an important role in granulopoiesis. The tumor suppressor function of C/EBPα is shown by the findings that loss of expression or function of C/EBPα in leukemic blasts contributes to a block in myeloid cell differentiation and to leukemia. C/EBPα mutations are fo...

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Autori principali: Pulikkan, John A, Dengler, Viola, Peer Zada, Abdul A, Kawasaki, Akira, Geletu, Mulu, Pasalic, Zlatana, Bohlander, Stefan K, Ryo, Akihide, Tenen, Daniel G, Behre, Gerhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923485/
https://ncbi.nlm.nih.gov/pubmed/20376080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.37
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