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Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα induced granulocytic differentiation via c-Jun in AML
The transcription factor C/EBPα plays an important role in granulopoiesis. The tumor suppressor function of C/EBPα is shown by the findings that loss of expression or function of C/EBPα in leukemic blasts contributes to a block in myeloid cell differentiation and to leukemia. C/EBPα mutations are fo...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923485/ https://ncbi.nlm.nih.gov/pubmed/20376080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.37 |
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