Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

Transcription factor CCAAT enhancer binding protein α (C/EBPα) is essential for granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master regulator of cell-cycle progression, by C/EBPα is pivotal for granulopoiesis. Recent studies show microRNA-223 (miR-223), a trans...

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Autors principals: Pulikkan, John A., Dengler, Viola, Peramangalam, Philomina S., Peer Zada, Abdul A., Müller-Tidow, Carsten, Bohlander, Stefan K., Tenen, Daniel G., Behre, Gerhard
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832809/
https://ncbi.nlm.nih.gov/pubmed/20029046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-240101
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