Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

Transcription factor C/EBPα is a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia. Deregulation of C/EBPα by microRNAs during granulopoiesis or acute myeloid leukemia development has not been studied. Here we show that oncogenic miR-182 is a strong regu...

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Publicat a:Nat Commun
Autors principals: Wurm, Alexander Arthur, Zjablovskaja, Polina, Kardosova, Miroslava, Gerloff, Dennis, Bräuer-Hartmann, Daniela, Katzerke, Christiane, Hartmann, Jens-Uwe, Benoukraf, Touati, Fricke, Stephan, Hilger, Nadja, Müller, Anne-Marie, Bill, Marius, Schwind, Sebastian, Tenen, Daniel G., Niederwieser, Dietger, Alberich-Jorda, Meritxell, Behre, Gerhard
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491528/
https://ncbi.nlm.nih.gov/pubmed/28663557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00032-6
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