PML/RARα-regulated miR-181a/b-cluster targets the tumor suppressor RASSF1A in Acute Promyelocytic Leukemia

In acute promyelocytic leukemia (APL), all-trans-retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. MicroRNAs are known to be critical players in the formation of the leukemic phenotype. In this study, we report downregulation of the miR-181a/b gene cl...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Bräuer-Hartmann, Daniela, Hartmann, Jens-Uwe, Wurm, Alexander A., Gerloff, Dennis, Katzerke, Christiane, Falzacappa, Maria Vittoria Verga, Pelicci, Pier Giuseppe, Müller-Tidow, Carsten, Tenen, Daniel G., Niederwieser, Dietger, Behre, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537849/
https://ncbi.nlm.nih.gov/pubmed/26041820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3521
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