IQGAP1 and IQGAP3 serve individually essential roles in normal epidermal homeostasis and tumor progression

IQGAP scaffolding proteins regulate many essential cellular processes including growth factor receptor signaling, cytoskeletal rearrangement, adhesion and proliferation, and are highly expressed in many cancers. Using genetically engineered human skin tissue in vivo, we demonstrate that diminished,...

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Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Monteleon, Christine L., McNeal, Andrew, Duperret, Elizabeth K., Oh, Seung Ja, Schapira, Emily, Ridky, Todd W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537348/
https://ncbi.nlm.nih.gov/pubmed/25848980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.140
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