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Farnesoid X receptor is essential for normal glucose homeostasis

The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory role in glucose homeostasis. FXR-null mice developed severe fatty liver and elevated circulating FFAs, which was associated with elevated se...

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Detalles Bibliográficos
Main Authors: Ma, Ke, Saha, Pradip K., Chan, Lawrence, Moore, David D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409738/
https://ncbi.nlm.nih.gov/pubmed/16557297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25604
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