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Farnesoid X receptor is essential for normal glucose homeostasis
The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory role in glucose homeostasis. FXR-null mice developed severe fatty liver and elevated circulating FFAs, which was associated with elevated se...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1409738/ https://ncbi.nlm.nih.gov/pubmed/16557297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25604 |
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