Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors

Fibroblast growth factor receptor 3 (FGFR3) activating mutations are drivers of malignancy in several human tissues, including bladder, lung, cervix, and blood. However, in skin, these mutations are associated predominantly with benign, common epidermal growths called seborrheic keratoses (SKs). How...

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Detalhes bibliográficos
Main Authors: Duperret, Elizabeth K, Oh, Seung Ja, McNeal, Andrew, Prouty, Stephen M, Ridky, Todd W
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050160/
https://ncbi.nlm.nih.gov/pubmed/24626198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28492
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