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The architecture of the spliceosomal U4/U6.U5 tri-snRNP
U4/U6.U5 tri-snRNP is a 1.5 MDa pre-assembled spliceosomal complex comprising U5 snRNA, extensively base-paired U4/U6 snRNAs and >30 proteins, including the key components Prp8, Brr2 and Snu114. The tri-snRNP combines with a pre-mRNA substrate bound to U1 and U2 snRNPs and transforms into a catal...
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| Publicado en: | Nature |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536768/ https://ncbi.nlm.nih.gov/pubmed/26106855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14548 |
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