The architecture of the spliceosomal U4/U6.U5 tri-snRNP

U4/U6.U5 tri-snRNP is a 1.5 MDa pre-assembled spliceosomal complex comprising U5 snRNA, extensively base-paired U4/U6 snRNAs and >30 proteins, including the key components Prp8, Brr2 and Snu114. The tri-snRNP combines with a pre-mRNA substrate bound to U1 and U2 snRNPs and transforms into a catal...

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Udgivet i:Nature
Main Authors: Nguyen, Thi Hoang Duong, Galej, Wojciech P., Bai, Xiao-chen, Savva, Christos G., Newman, Andrew J., Scheres, Sjors H. W., Nagai, Kiyoshi
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536768/
https://ncbi.nlm.nih.gov/pubmed/26106855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14548
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