A molecular tweezer antagonizes seminal amyloids and HIV infection

Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we establish that CLR01, a ‘molecular tweezer’ specific...

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Foilsithe in:eLife
Main Authors: Lump, Edina, Castellano, Laura M, Meier, Christoph, Seeliger, Janine, Erwin, Nelli, Sperlich, Benjamin, Stürzel, Christina M, Usmani, Shariq, Hammond, Rebecca M, von Einem, Jens, Gerold, Gisa, Kreppel, Florian, Bravo-Rodriguez, Kenny, Pietschmann, Thomas, Holmes, Veronica M, Palesch, David, Zirafi, Onofrio, Weissman, Drew, Sowislok, Andrea, Wettig, Burkhard, Heid, Christian, Kirchhoff, Frank, Weil, Tanja, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Sanchez-Garcia, Elsa, Winter, Roland, Shorter, James, Münch, Jan
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2015
Ábhair:
Biochemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536748/
https://ncbi.nlm.nih.gov/pubmed/26284498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05397
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