Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers

[Image: see text] Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular ligand (CLR01) destroys enveloped viruses, including HIV,...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Weil, Tatjana, Groß, Rüdiger, Röcker, Annika, Bravo-Rodriguez, Kenny, Heid, Christian, Sowislok, Andrea, Le, My-Hue, Erwin, Nelli, Dwivedi, Mridula, Bart, Stephen M., Bates, Paul, Wettstein, Lukas, Müller, Janis A., Harms, Mirja, Sparrer, Konstantin, Ruiz-Blanco, Yasser B., Stürzel, Christina M., von Einem, Jens, Lippold, Sina, Read, Clarissa, Walther, Paul, Hebel, Marco, Kreppel, Florian, Klärner, Frank-Gerrit, Bitan, Gal, Ehrmann, Michael, Weil, Tanja, Winter, Roland, Schrader, Thomas, Shorter, James, Sanchez-Garcia, Elsa, Münch, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523239/
https://ncbi.nlm.nih.gov/pubmed/32926779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06400
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