A molecular tweezer antagonizes seminal amyloids and HIV infection

Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we establish that CLR01, a ‘molecular tweezer’ specific...

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Vydáno v:eLife
Hlavní autoři: Lump, Edina, Castellano, Laura M, Meier, Christoph, Seeliger, Janine, Erwin, Nelli, Sperlich, Benjamin, Stürzel, Christina M, Usmani, Shariq, Hammond, Rebecca M, von Einem, Jens, Gerold, Gisa, Kreppel, Florian, Bravo-Rodriguez, Kenny, Pietschmann, Thomas, Holmes, Veronica M, Palesch, David, Zirafi, Onofrio, Weissman, Drew, Sowislok, Andrea, Wettig, Burkhard, Heid, Christian, Kirchhoff, Frank, Weil, Tanja, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Sanchez-Garcia, Elsa, Winter, Roland, Shorter, James, Münch, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536748/
https://ncbi.nlm.nih.gov/pubmed/26284498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05397
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