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Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration

Sos-1 and Sos-2 are ubiquitously expressed Ras-Guanine Exchange Factors involved in Erk-MAP kinase pathway activation. Using mice lacking genes encoding Sos-1 and Sos-2, we evaluated the role of these proteins in peripheral T-cell signaling and function. Our results confirmed that TCR-mediated Erk a...

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Publicado en:Eur J Immunol
Main Authors: Guittard, Geoffrey, Kortum, Robert L, Balagopalan, Lakshmi, Çuburu, Nicolas, Nguyen, Phan, Sommers, Connie L, Samelson, Lawrence E
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536155/
https://ncbi.nlm.nih.gov/pubmed/25973715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445226
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