Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice

RAS signaling is central to many cellular processes and SOS proteins promote RAS activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1(f/f) Sos2(−/−) mice to CD4-Cre transgenic mice. We previously reported an effect of these mutations on T cell signaling and T cell m...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Guittard, Geoffrey, Gallardo, Devorah L., Li, Wenmei, Melis, Nicolas, Lui, Julian C., Kortum, Robert L., Shakarishvili, Nicholas G., Huh, Sunmee, Baron, Jeffrey, Weigert, Roberto, Kramer, Joshua A., Samelson, Lawrence E., Sommers, Connie L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362643/
https://ncbi.nlm.nih.gov/pubmed/28386265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00343
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