Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice

RAS signaling is central to many cellular processes and SOS proteins promote RAS activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1(f/f) Sos2(−/−) mice to CD4-Cre transgenic mice. We previously reported an effect of these mutations on T cell signaling and T cell m...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Guittard, Geoffrey, Gallardo, Devorah L., Li, Wenmei, Melis, Nicolas, Lui, Julian C., Kortum, Robert L., Shakarishvili, Nicholas G., Huh, Sunmee, Baron, Jeffrey, Weigert, Roberto, Kramer, Joshua A., Samelson, Lawrence E., Sommers, Connie L.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362643/
https://ncbi.nlm.nih.gov/pubmed/28386265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00343
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