Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

Translation initiation in eukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal subunit, eIF1, eIF1A, eIF3, ternary complex (eIF2-GTP-Met-tRNA(i)), and eIF5. The PIC, in an open conformation, attaches to the 5′ end of the mRNA and scans to locate the sta...

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Publié dans:Mol Cell
Auteurs principaux: Llácer, Jose L., Hussain, Tanweer, Marler, Laura, Aitken, Colin Echeverría, Thakur, Anil, Lorsch, Jon R., Hinnebusch, Alan G., Ramakrishnan, V.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534855/
https://ncbi.nlm.nih.gov/pubmed/26212456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.06.033
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