Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (P(OUT)) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable confor...

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Main Authors: Hussain, Tanweer, Llácer, Jose L., Fernández, Israel S., Munoz, Antonio, Martin-Marcos, Pilar, Savva, Christos G., Lorsch, Jon R., Hinnebusch, Alan G., Ramakrishnan, V.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217140/
https://ncbi.nlm.nih.gov/pubmed/25417110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.10.001
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