Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation complex

eIF5 is the GTPase activating protein (GAP) for the eIF2·GTP·Met-tRNA(i)(Met) ternary complex with a critical role in initiation codon selection. Previous work suggested that the eIF5 mutation G31R/SUI5 elevates initiation at UUG codons by increasing GAP function. Subsequent work implicated eIF5 in...

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Detalhes bibliográficos
Main Authors: Saini, Adesh K., Nanda, Jagpreet S., Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R., Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150770/
https://ncbi.nlm.nih.gov/pubmed/25114053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku653
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