Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy

In the current model of translation initiation by the scanning mechanism, eIF1 promotes an open conformation of the 40S subunit competent for rapidly loading the eIF2·GTP·Met-tRNA(i) ternary complex (TC) in a metastable conformation (P(OUT)) capable of sampling triplets entering the P site while blo...

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Autores principales: Martin-Marcos, Pilar, Nanda, Jagpreet S., Luna, Rafael E., Zhang, Fan, Saini, Adesh K., Cherkasova, Vera A., Wagner, Gerhard, Lorsch, Jon R., Hinnebusch, Alan G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895268/
https://ncbi.nlm.nih.gov/pubmed/24335188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042069.113
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