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Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome

eIF1A is the eukaryotic ortholog of bacterial translation initiation factor IF1, but contains a helical domain and long unstructured N-terminal tail (NTT) and C-terminal tail (CTT) absent in IF1. Here, we identify elements in these accessory regions of eIF1A with dual functions in binding methionyl...

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書誌詳細
主要な著者: Saini, Adesh K., Nanda, Jagpreet S., Lorsch, Jon R., Hinnebusch, Alan G.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2010
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802195/
https://ncbi.nlm.nih.gov/pubmed/20048003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1871910
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