Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome

eIF1A is the eukaryotic ortholog of bacterial translation initiation factor IF1, but contains a helical domain and long unstructured N-terminal tail (NTT) and C-terminal tail (CTT) absent in IF1. Here, we identify elements in these accessory regions of eIF1A with dual functions in binding methionyl...

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Hlavní autoři: Saini, Adesh K., Nanda, Jagpreet S., Lorsch, Jon R., Hinnebusch, Alan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2010
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802195/
https://ncbi.nlm.nih.gov/pubmed/20048003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1871910
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