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Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation of Met-tRNA(i) in a ‘P(IN)’ state, which is antagonized by the factor eIF1. eIF5 is a GTPase activating protein (GAP) of eIF2 that additionally promotes stringent AUG selection, but the molecular basis of its du...
Guardat en:
| Publicat a: | eLife |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6298780/ https://ncbi.nlm.nih.gov/pubmed/30475211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39273 |
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