Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation of Met-tRNA(i) in a ‘P(IN)’ state, which is antagonized by the factor eIF1. eIF5 is a GTPase activating protein (GAP) of eIF2 that additionally promotes stringent AUG selection, but the molecular basis of its du...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Llácer, Jose Luis, Hussain, Tanweer, Saini, Adesh K, Nanda, Jagpreet Singh, Kaur, Sukhvir, Gordiyenko, Yuliya, Kumar, Rakesh, Hinnebusch, Alan G, Lorsch, Jon R, Ramakrishnan, V
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
Sujets:
Structural Biology and Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298780/
https://ncbi.nlm.nih.gov/pubmed/30475211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39273
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