Coordinated Movements of Eukaryotic Translation Initiation Factors eIF1, eIF1A, and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex

Accurate recognition of the start codon in an mRNA by the eukaryotic translation preinitiation complex (PIC) is essential for proper gene expression. The process is mediated by eukaryotic translation initiation factors (eIFs) in conjunction with the 40 S ribosomal subunit and (initiator) tRNA(i). He...

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Bibliographische Detailangaben
Hauptverfasser: Nanda, Jagpreet S., Saini, Adesh K., Muñoz, Antonio M., Hinnebusch, Alan G., Lorsch, Jon R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581429/
https://ncbi.nlm.nih.gov/pubmed/23293029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.440693
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