Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

Dioxygenases of the TET (Ten-Eleven Translocation) family produce oxidized methylcytosines, intermediates in DNA demethylation, as well as new epigenetic marks. Here we show data suggesting that TET proteins maintain the consistency of gene transcription. Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) d...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kang, Jinsuk, Lienhard, Matthias, Pastor, William A., Chawla, Ashu, Novotny, Mark, Tsagaratou, Ageliki, Lasken, Roger S., Thompson, Elizabeth C., Surani, M. Azim, Koralov, Sergei B., Kalantry, Sundeep, Chavez, Lukas, Rao, Anjana
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534209/
https://ncbi.nlm.nih.gov/pubmed/26199412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510510112
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi