Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

Dioxygenases of the TET (Ten-Eleven Translocation) family produce oxidized methylcytosines, intermediates in DNA demethylation, as well as new epigenetic marks. Here we show data suggesting that TET proteins maintain the consistency of gene transcription. Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) d...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Kang, Jinsuk, Lienhard, Matthias, Pastor, William A., Chawla, Ashu, Novotny, Mark, Tsagaratou, Ageliki, Lasken, Roger S., Thompson, Elizabeth C., Surani, M. Azim, Koralov, Sergei B., Kalantry, Sundeep, Chavez, Lukas, Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534209/
https://ncbi.nlm.nih.gov/pubmed/26199412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510510112
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