Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

Dioxygenases of the Ten-Eleven Translocation (TET) family are 5-methylcytosine oxidases that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidation products in DNA. We show that Tet1 and Tet2 have distinct roles in regulating 5hmC in mouse embryonic stem cells (mESC)....

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Autores principales: Huang, Yun, Chavez, Lukas, Chang, Xing, Wang, Xue, Pastor, William A., Kang, Jinsuk, Zepeda-Martínez, Jorge A., Pape, Utz J., Jacobsen, Steven E., Peters, Bjoern, Rao, Anjana
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910590/
https://ncbi.nlm.nih.gov/pubmed/24474761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322921111
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