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Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions
Cytochrome P450 3A4 (CYP3A4) is the major and most important drug-metabolizing enzyme in humans that oxidizes and clears over a half of all administered pharmaceuticals. This is possible because CYP3A4 is promiscuous with respect to substrate binding and has the ability to catalyze diverse oxidative...
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| Vydáno v: | Adv Exp Med Biol |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532289/ https://ncbi.nlm.nih.gov/pubmed/26002732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-319-16009-2_3 |
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