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Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions

Cytochrome P450 3A4 (CYP3A4) is the major and most important drug-metabolizing enzyme in humans that oxidizes and clears over a half of all administered pharmaceuticals. This is possible because CYP3A4 is promiscuous with respect to substrate binding and has the ability to catalyze diverse oxidative...

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Bibliographische Detailangaben
Veröffentlicht in:Adv Exp Med Biol
Hauptverfasser: Sevrioukova, Irina F., Poulos, Thomas L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532289/
https://ncbi.nlm.nih.gov/pubmed/26002732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-319-16009-2_3
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