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UNDERSTANDING THE MECHANISM OF CYTOCHROME P450 3A4: RECENT ADVANCES AND REMAINING PROBLEMS

Cytochromes P450 (CYPs) represent a diverse group of heme-thiolate proteins found in almost all organisms. CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen. Among 57 human P450s, the 3A4 i...

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Bibliografiske detaljer
Main Authors: Sevrioukova, Irina F., Poulos, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787833/
https://ncbi.nlm.nih.gov/pubmed/23018626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2dt31833d
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