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Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4
Human cytochrome P450 3A4 (CYP3A4) is a major hepatic and intestinal enzyme that oxidizes more than 60% of administered therapeutics. Knowledge of how CYP3A4 adjusts and reshapes the active site to regioselectively oxidize chemically diverse compounds is critical for better understanding structure–f...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5255590/ https://ncbi.nlm.nih.gov/pubmed/28031486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616198114 |
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