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Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism

Inactivation of human drug-metabolizing cytochrome P450 3A4 (CYP3A4) could lead to serious adverse events such as drug-drug interactions and toxicity. However, when properly controlled, CYP3A4 inhibition may be beneficial as it can improve clinical efficacy of co-administered therapeutics that other...

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Publicado en:Curr Top Med Chem
Main Authors: Sevrioukova, Irina F., Poulos, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530633/
https://ncbi.nlm.nih.gov/pubmed/24805065
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