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Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism
Inactivation of human drug-metabolizing cytochrome P450 3A4 (CYP3A4) could lead to serious adverse events such as drug-drug interactions and toxicity. However, when properly controlled, CYP3A4 inhibition may be beneficial as it can improve clinical efficacy of co-administered therapeutics that other...
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| Udgivet i: | Curr Top Med Chem |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530633/ https://ncbi.nlm.nih.gov/pubmed/24805065 |
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