Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling

Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a “synthetic lethal” interaction between oncogenic BRAF V600E and a ketogenic enzy...

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Vydáno v:Mol Cell
Hlavní autoři: Kang, Hee-Bum, Fan, Jun, Lin, Ruiting, Elf, Shannon, Ji, Quanjiang, Zhao, Liang, Jin, Lingtao, Seo, Jae Ho, Shan, Changliang, Arbiser, Jack L., Cohen, Cynthia, Brat, Daniel, Miziorko, Henry M., Kim, Eunhee, Abdel-Wahab, Omar, Merghoub, Taha, Fröhling, Stefan, Scholl, Claudia, Tamayo, Pablo, Barbie, David A., Zhou, Lu, Pollack, Brian P., Fisher, Kevin, Kudchadkar, Ragini R., Lawson, David H., Sica, Gabriel, Rossi, Michael, Lonial, Sagar, Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Boggon, Titus J., He, Chuan, Kang, Sumin, Chen, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530073/
https://ncbi.nlm.nih.gov/pubmed/26145173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.037
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