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Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling
Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a “synthetic lethal” interaction between oncogenic BRAF V600E and a ketogenic enzy...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530073/ https://ncbi.nlm.nih.gov/pubmed/26145173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.037 |
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