Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling

Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a “synthetic lethal” interaction between oncogenic BRAF V600E and a ketogenic enzy...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Cell
Κύριοι συγγραφείς: Kang, Hee-Bum, Fan, Jun, Lin, Ruiting, Elf, Shannon, Ji, Quanjiang, Zhao, Liang, Jin, Lingtao, Seo, Jae Ho, Shan, Changliang, Arbiser, Jack L., Cohen, Cynthia, Brat, Daniel, Miziorko, Henry M., Kim, Eunhee, Abdel-Wahab, Omar, Merghoub, Taha, Fröhling, Stefan, Scholl, Claudia, Tamayo, Pablo, Barbie, David A., Zhou, Lu, Pollack, Brian P., Fisher, Kevin, Kudchadkar, Ragini R., Lawson, David H., Sica, Gabriel, Rossi, Michael, Lonial, Sagar, Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Boggon, Titus J., He, Chuan, Kang, Sumin, Chen, Jing
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2015
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530073/
https://ncbi.nlm.nih.gov/pubmed/26145173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.037
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