Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9

Precise temporal control of gene expression or deletion is critical for elucidating gene function in biological systems. However, establishment of human pluripotent stem cell (hPSC) lines with inducible gene knockout (iKO) remains challenging. We explored building iKO hPSC lines by combining CRISPR/...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Chen, Yuejun, Cao, Jingyuan, Xiong, Man, Petersen, Andrew J., Dong, Yi, Tao, Yunlong, Huang, Cindy Tzu-Ling, Du, Zhongwei, Zhang, Su-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530040/
https://ncbi.nlm.nih.gov/pubmed/26145478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.06.001
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