More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

Enterovirus 71 (HEV71) epidemics amongst children and infants result mainly in mild symptoms, however, especially in the Asia-Pacific region, infection can be fatal. At present no therapies are available. We have used structural analysis of the complete virus to guide the design of HEV71 inhibitors....

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Bibliografiske detaljer
Udgivet i:Nat Struct Mol Biol
Main Authors: De Colibus, Luigi, Wang, Xiangxi, Spyrou, John A. B., Kelly, James, Ren, Jingshan, Grimes, Jonathan, Puerstinger, Gerhard, Stonehouse, Nicola, Walter, Thomas S., Hu, Zhongyu, Wang, Junzhi, Li, Xuemei, Peng, Wei, Rowlands, David, Fry, Elizabeth E., Rao, Zihe, Stuart, David I.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530014/
https://ncbi.nlm.nih.gov/pubmed/24509833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2769
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