More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

Enterovirus 71 (HEV71) epidemics amongst children and infants result mainly in mild symptoms, however, especially in the Asia-Pacific region, infection can be fatal. At present no therapies are available. We have used structural analysis of the complete virus to guide the design of HEV71 inhibitors....

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Publié dans:Nat Struct Mol Biol
Auteurs principaux: De Colibus, Luigi, Wang, Xiangxi, Spyrou, John A. B., Kelly, James, Ren, Jingshan, Grimes, Jonathan, Puerstinger, Gerhard, Stonehouse, Nicola, Walter, Thomas S., Hu, Zhongyu, Wang, Junzhi, Li, Xuemei, Peng, Wei, Rowlands, David, Fry, Elizabeth E., Rao, Zihe, Stuart, David I.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530014/
https://ncbi.nlm.nih.gov/pubmed/24509833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2769
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