A Pan-GTPase Inhibitor as a Molecular Probe

Overactive GTPases have often been linked to human diseases. The available inhibitors are limited and have not progressed far in clinical trials. We report here a first-in-class small molecule pan-GTPase inhibitor discovered from a high throughput screening campaign. The compound CID1067700 inhibits...

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Pubblicato in:PLoS One
Autori principali: Hong, Lin, Guo, Yuna, BasuRay, Soumik, Agola, Jacob O., Romero, Elsa, Simpson, Denise S., Schroeder, Chad E., Simons, Peter, Waller, Anna, Garcia, Matthew, Carter, Mark, Ursu, Oleg, Gouveia, Kristine, Golden, Jennifer E., Aubé, Jeffrey, Wandinger-Ness, Angela, Sklar, Larry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527730/
https://ncbi.nlm.nih.gov/pubmed/26247207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134317
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