A Competitive Nucleotide Binding Inhibitor: In vitro Characterization of Rab7 GTPase Inhibition

Mapping the functionality of GTPases through small molecule inhibitors represents an underexplored area in large part due to the lack of suitable compounds. Here we report on the small chemical molecule 2-(benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid (PubCh...

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Detalhes bibliográficos
Main Authors: Agola, Jacob O., Hong, Lin, Surviladze, Zurab, Ursu, Oleg, Waller, Anna, Strouse, J. Jacob, Simpson, Denise S., Schroeder, Chad E., Oprea, Tudor I., Golden, Jennifer E., Aubé, Jeffrey, Buranda, Tione, Sklar, Larry A., Wandinger-Ness, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440014/
https://ncbi.nlm.nih.gov/pubmed/22486388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3001099
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