Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

Rho family GTPases (including Rac, Rho and Cdc42) collectively control cell proliferation, adhesion and migration and are of interest as functional therapeutic targets in numerous epithelial cancers. Based on high throughput screening of the Prestwick Chemical Library(®) and cheminformatics we ident...

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Publicado en:PLoS One
Autores principales: Oprea, Tudor I., Sklar, Larry A., Agola, Jacob O., Guo, Yuna, Silberberg, Melina, Roxby, Joshua, Vestling, Anna, Romero, Elsa, Surviladze, Zurab, Murray-Krezan, Cristina, Waller, Anna, Ursu, Oleg, Hudson, Laurie G., Wandinger-Ness, Angela
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641600/
https://ncbi.nlm.nih.gov/pubmed/26558612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142182
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