Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

Rho family GTPases (including Rac, Rho and Cdc42) collectively control cell proliferation, adhesion and migration and are of interest as functional therapeutic targets in numerous epithelial cancers. Based on high throughput screening of the Prestwick Chemical Library(®) and cheminformatics we ident...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Oprea, Tudor I., Sklar, Larry A., Agola, Jacob O., Guo, Yuna, Silberberg, Melina, Roxby, Joshua, Vestling, Anna, Romero, Elsa, Surviladze, Zurab, Murray-Krezan, Cristina, Waller, Anna, Ursu, Oleg, Hudson, Laurie G., Wandinger-Ness, Angela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641600/
https://ncbi.nlm.nih.gov/pubmed/26558612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142182
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