Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

Rho family GTPases (including Rac, Rho and Cdc42) collectively control cell proliferation, adhesion and migration and are of interest as functional therapeutic targets in numerous epithelial cancers. Based on high throughput screening of the Prestwick Chemical Library(®) and cheminformatics we ident...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Oprea, Tudor I., Sklar, Larry A., Agola, Jacob O., Guo, Yuna, Silberberg, Melina, Roxby, Joshua, Vestling, Anna, Romero, Elsa, Surviladze, Zurab, Murray-Krezan, Cristina, Waller, Anna, Ursu, Oleg, Hudson, Laurie G., Wandinger-Ness, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641600/
https://ncbi.nlm.nih.gov/pubmed/26558612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142182
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