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Identification of a Small GTPase Inhibitor using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay

Small GTPases are key regulators of cellular activity and represent novel targets for the treatment of human diseases using small molecule inhibitors. We describe a multiplex, flow cytometry bead-based assay for the identification and characterization of inhibitors or activators of small GTPases. Si...

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Autori principali: Surviladze, Zurab, Waller, Anna, Wu, Yang, Romero, Elsa, Edwards, Bruce S., Wandinger-Ness, Angela, Sklar, Larry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433230/
https://ncbi.nlm.nih.gov/pubmed/20008126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057109352240
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