Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation.

We have used derivatized antisense oligodeoxynucleotides both in vitro and in vivo specifically to inhibit translation of the activated human oncogene Ha-ras. The oligonucleotides (5'-CCACACCGA-3') were targeted to a region of Ha-ras mRNA including the point mutation G----T at the 12th cod...

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Main Authors: Saison-Behmoaras, T, Tocqué, B, Rey, I, Chassignol, M, Thuong, N T, Hélène, C
格式: Artigo
語言:Inglês
出版: 1991
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC452764/
https://ncbi.nlm.nih.gov/pubmed/1850694
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