Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice.

Ras oncogenes owe their transforming properties to single point mutations in the sequence coding for the active site of the p21 protein. These mutations lead to changes in cellular proliferation and induce tumorigenic properties. Point mutations represent a well-defined target for antisense oligonuc...

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Detalhes bibliográficos
Main Authors: Schwab, G, Chavany, C, Duroux, I, Goubin, G, Lebeau, J, Hélène, C, Saison-Behmoaras, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC45040/
https://ncbi.nlm.nih.gov/pubmed/7937975
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