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Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice.

Ras oncogenes owe their transforming properties to single point mutations in the sequence coding for the active site of the p21 protein. These mutations lead to changes in cellular proliferation and induce tumorigenic properties. Point mutations represent a well-defined target for antisense oligonuc...

詳細記述

保存先:
書誌詳細
主要な著者: Schwab, G, Chavany, C, Duroux, I, Goubin, G, Lebeau, J, Hélène, C, Saison-Behmoaras, T
フォーマット: Artigo
言語:Inglês
出版事項: 1994
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC45040/
https://ncbi.nlm.nih.gov/pubmed/7937975
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