Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice.

Ras oncogenes owe their transforming properties to single point mutations in the sequence coding for the active site of the p21 protein. These mutations lead to changes in cellular proliferation and induce tumorigenic properties. Point mutations represent a well-defined target for antisense oligonuc...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Schwab, G, Chavany, C, Duroux, I, Goubin, G, Lebeau, J, Hélène, C, Saison-Behmoaras, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937975/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10460
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