Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice.

Ras oncogenes owe their transforming properties to single point mutations in the sequence coding for the active site of the p21 protein. These mutations lead to changes in cellular proliferation and induce tumorigenic properties. Point mutations represent a well-defined target for antisense oligonuc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Schwab, G, Chavany, C, Duroux, I, Goubin, G, Lebeau, J, Hélène, C, Saison-Behmoaras, T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1994
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC45040/
https://ncbi.nlm.nih.gov/pubmed/7937975
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