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Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells.
Antisense oligodeoxynucleotides targeted to Ha-ras mRNA have been designed to discriminate between the codon 12-mutated oncogene and the normal proto-oncogene. An in vitro assay using two different sources of RNase H (rabbit reticulocyte lysates and nuclear extract from HeLa cells) was used to chara...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
1995
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307218/ https://ncbi.nlm.nih.gov/pubmed/7567450 |
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