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Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells.

Antisense oligodeoxynucleotides targeted to Ha-ras mRNA have been designed to discriminate between the codon 12-mutated oncogene and the normal proto-oncogene. An in vitro assay using two different sources of RNase H (rabbit reticulocyte lysates and nuclear extract from HeLa cells) was used to chara...

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Detalhes bibliográficos
Main Authors: Duroux, I, Godard, G, Boidot-Forget, M, Schwab, G, Hélène, C, Saison-Behmoaras, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC307218/
https://ncbi.nlm.nih.gov/pubmed/7567450
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