Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation.

We have used derivatized antisense oligodeoxynucleotides both in vitro and in vivo specifically to inhibit translation of the activated human oncogene Ha-ras. The oligonucleotides (5'-CCACACCGA-3') were targeted to a region of Ha-ras mRNA including the point mutation G----T at the 12th cod...

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Detaylı Bibliyografya
Asıl Yazarlar: Saison-Behmoaras, T, Tocqué, B, Rey, I, Chassignol, M, Thuong, N T, Hélène, C
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1991
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC452764/
https://ncbi.nlm.nih.gov/pubmed/1850694
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