STRUCTURAL BASIS OF TRANSCRIPTION INHIBITION BY CBR HYDROXAMIDINES AND CBR PYRAZOLES

CBR hydroxamidines are small-molecule inhibitors of bacterial RNA polymerase (RNAP) discovered through high-throughput-screening of synthetic-compound libraries. CBR pyrazoles are structurally related RNAP inhibitors discovered through “scaffold hopping” from CBR hydroxamidines. CBR hydroxamidines a...

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Publicat a:Structure
Autors principals: Feng, Yu, Degen, David, Wang, Xinyue, Gigliotti, Matthew, Liu, Shuang, Zhang, Yu, Das, Deepankar, Michalchuk, Trevor, Ebright, Yon W., Talaue, Meliza, Connell, Nancy, Ebright, Richard H.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526357/
https://ncbi.nlm.nih.gov/pubmed/26190576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.009
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